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Basic Biochemistry

Humans adapt to technology very easily. We can drive cars without knowing what’s under the hood. We can use computers and smartphones much the same way. Among all the different pieces of technology used by us, an obvious but often overlooked example is that of our own body. Not many of us think about the Biochemistry that is always taking place in our body.

This course will link everyday experiences with topics that lie at the core of Biochemistry.

By studying how our body transforms sugars, fats, and the proteins, we will follow the transformations of the food stuffs in our breakfasts, lunches and dinners. We will read lectures from Nobel Laureates, we will peer into the active sites of enzymes, and we see how modern medicine deals with things going wrong.

COURSE FLYER

Lectures
Prerequisites

Some organic chemistry.

Syllabus

This course will taught in an essay-type format on Reddit.

SYLLABUS

At its core Biochemistry really deals with two direct yet deceptively simple questions. These are: (1) where did it come from, and (2) where does it go?

Lecture 1 -- The hemoglobin-oxygen complex: We will use the two core biochemical questions to interrogate the hemoglobin-oxygen complex. We will touch upon heme biosynthesis and breakdown, oxygen transport to the cells, and the expression and degradation of proteins.

Lecture 2 -- The Electron Transport Chain and Oxidative Phosphorylation: We will trace the source of electrons that are added to oxygen to generate water. We will also learn how a gradient of protons is converted into ATP.

Lecture 3 – Structures: We will focus on the structures of FADH2 and NADH. We will also play close attention to the structures of folate, guanine, adenine, uracil, thymine, cytosine, thiamine and pyridoxine. We will bank on the knowledge of these structures for the familiarity we need as we journey deeper into Biochemistry.

Lecture 4 – The high-carb meal: We will eat a high carbohydrate meal, (in our imaginations) and then we will herd the carbons of glucose down the glycolysis pathway, and around the TCA cycle. Then, we will travel with these electrons up the Electron Transport Chain, all the way to oxygen, to make water.

Lecture 5 -- Glycogen and Fatty Acids: We will store some carbohydrates as glycogen, and we will funnel some of the carbon from carbohydrates into fatty acids. We will also study glycogen breakdown and fatty acid breakdown.

Lecture 6 – The high-fat, high-cholesterol meal: We will eat a 4-egg cheese omelet (again in our imaginations) and learn how lipids are digested, how they are packaged and shipped into the blood stream. We will also travel on a few different lipid cargo-ships in our blood stream.

Lecture 7 – The all-meat meal. We will study protein digestion, and the urea cycle. By now, all of us should be experts at herding carbons into the TCA cycle.

Lecture 8 – Purines and Pyrimidines: We will ask the two core biochemical question to the molecules that make up our DNA. Understandably, in cancerous tissues these biosynthetic pathways work overtime, and we will see how some anticancer treatments are based on chemically inhibiting these pathways.

Additional information

GENERAL DISCLAIMER: This aim of this course is to provide an overview of Biochemistry, and to convey its importance to a general audience. Selected topics from Biochemistry are presented to the best of my own ability and current understanding. However, it is possible that some of my presentations may not fit with what is commonly accepted. In those cases, the student is to give less importance to my presentations, and to give more importance to the concepts that fit with what is commonly accepted. This is an evolving course, and I appreciate feedback.

Teacher qualifications

PhD, Medicinal Chemistry.

Latest Update
Lecture 8 is now online (2013-07-02 19:59:56)

"The FINAL lecture on PYRIMIDINES AND PURINES is now online.

I hope you all enjoyed this course.

If you haven't already, please evaluate the course by clicking on this Survey Link

Thanks. "

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908. Skeetabump
909. jack564
910. evita77
911. babusona422
912. AlexMotorcycles
913. salthoff
914. cheesecakeandtea
915. Samson
916. 101124
917. synthetichug
918. minor6th
919. purpleskyy
920. alys_smile
921. teddy16426
922. deboadesida
923. Machtuebernahme
924. Richo1337
925. kkitburi
926. Mystery
927. OnlineLearner
928. rutushe
929. anya5
930. ThisisNOTbono2
931. Ena
932. gpereira
933. vaidatje
934. seidskald
935. cmajor13
936. HappyPanther
937. kataleesi
938. smilesrevolution
939. Dalmaciasikang1
940. SaraJamous
941. captpunkrogers
942. njflyguy
943. Verbery
944. cschwarz3
945. noztre
946. benyadigg
947. burubaxair
948. kunena08
949. Buck_Cletus_the_third
950. nuraaqillah
951. Vdaae
952. EvilEgg
953. KaminskL
954. xhyperamp
955. Ayama
956. TKDPlatypus
957. noahproductions
958. Lamatam
959. nasbelyakova
960. Tallkobben
961. nelsonng
962. romodinho
963. divagat3
964. Bibi12
965. nuni_maimuni
966. expansion
967. RBM
968. espada18
969. ChickenSammich
970. seanknight
971. sumwun21
972. IamGideon
973. lkfjlkrnfrr
974. takamahu
975. yukikat19
976. dahimes
977. sangsami
978. cfergani8
979. zackman558
980. ElizabethStanley
981. dumiaz
982. tylerspears6
983. Ssiyanwal
984. starskip
985. evdoyle
986. arianasvm
987. Jasminesky
988. gargambagel
989. mojojo
990. serenataco
991. sobh
992. bwhauf
993. jusdreinjusdaun
994. lorrainemarden
995. __hsams__
996. cioly
997. Durumu
998. cmiles
999. 07_
1000. lilithsposse
1001. zellekley
1002. SchizoPsychoMan
1003. treversotiropoulos
1004. PanPIp
1005. the_intoxicologist
1006. conquestinvividcolor
1007. evagavgiotaki
1008. caiotemon
1009. krampulus
1010. Reubanman
1011. christhepolakk
1012. kaltien
1013. bigcockatiels
1014. rsiva98
1015. JemmaD0508
1016. gravynsfw
1017. irawkz
1018. topkek
1019. bar_rachman
1020. DuesExMachina96
1021. purpletomato
1022. Markovic
1023. nofapemergency
1024. blindarrow02
1025. Mete0r1t3
1026. shaynee
1027. sevenstarsofstef
1028. aalowell
1029. ToneF
1030. bobbiburrows2
1031. raremagikarp
1032. silanderhatche
1033. scott.li
1034. Lilt_Bridge
1035. denitsa.harizanova
1036. sabinasosman
1037. Thorhey
1038. Flazze
1039. almusbahi23
1040. antnh1
1041. illusivedude
1042. LEVLEARN
1043. samybouisri
1044. osbornhodges2000
1045. Lanaaa
1046. dowserjr
1047. mmmori
1048. sakura_fantasix
1049. bomfilho
1050. cnading
1051. nishai
1052. AlbertFlasher
1053. cranbronkey
1054. sarah.muschiol
1055. kayeels
1056. mariluzgarcia
1057. lkira
1058. spinsurgeon
1059. jayneeee
1060. morganaha
1061. KobaYounes
1062. Veelayouth
1063. inhume
1064. eallin
1065. Monica101
1066. ChairDeBurlap
1067. mikepacas
1068. captaingreek
1069. Brenda3012
1070. AsianWuChink
1071. personiamsomeone
1072. theEMPTYlife
1073. gabbystolton
1074. mtmeador
1075. euclidlyptus
1076. Prototyperip
1077. victoriaferrete
1078. Voldemort
1079. DreDre
1080. fadwa
1081. Hebert002
1082. imStuuuuuck
1083. gracicles13
1084. Macmic21
1085. Clathrin
1086. ElectricSeahorse
1087. konanced
1088. vijayr98
1089. AlphaSapien
1090. esophagor
1091. kd73
1092. naeu
1093. RajatTyagi
1094. schmiter
1095. stickfigure_1715
1096. Phantom1412
1097. dffnflre
1098. nobbs
1099. ayoleah
1100. caliooppub
1101. beshlik
1102. taartun
1103. nlpkid
1104. improvementhiiip
1105. VaultGirl
1106. JaiEzikeil
1107. MooseRuse
1108. cmdrcaboose2
1109. Fullscreen_Math
1110. MTatro
1111. myMasqueradee
1112. Smp
1113. jtazzk
1114. Jayven_Roman
1115. Doominated
1116. abe-solotely-intel
1117. packback1
1118. sud-rhein
1119. youniqesparklez
1120. ejemelihenry
1121. planetarium
1122. ChemLover
1123. Afmoret
1124. spark34
1125. masterboki
1126. Greateggplant
1127. entfish
1128. hashanthisuraweera
1129. d0naLd
1130. Alicia
1131. annastillman
1132. zssmith1994
1133. Paradigmshift68
1134. dinara
1135. desaishrey
1136. RobRod
1137. selits
1138. kijawa
1139. ritatheexplorer
1140. hyperlux
1141. jacobab43
1142. Russont
1143. tha.jokr
1144. msmaddox25
1145. sasuke1992
1146. Syeeric
1147. madhatrabbit
1148. the_oneand_only89
1149. sienaplacino
1150. ArturoMazon
1151. nabill
1152. CehdHab
1153. salman
1154. SeoulBlossom
1155. reedyboy2012
1156. cinemacookie
1157. kantijaya
1158. moodette
1159. ktso
1160. Riana90
1161. rjycnfynby
1162. Gundas3073
1163. 1_crappuccino_pls
1164. Geekadelphia1
1165. greenredidunno
1166. alekseilyushkin
1167. notacurlyfry
1168. jerryedvds
1169. gutubu
1170. jediejr
1171. brichess
1172. budsofmay
1173. naterific
1174. Slas
1175. BioHazard9
1176. Wolf_meets_Raven
1177. lifesfare
1178. balto
1179. Whereabouts-Unknown
1180. InfiniDL
1181. marcusv1
1182. bleepblobbloop
1183. DeccyBrus
1184. ViIVi
1185. nukeduke
1186. SeanBoult
1187. 042smartkid
1188. thecosmicbean
1189. sboco
1190. 100prcntDar
1191. crisbalas
1192. rifraq
1193. Diego1995
1194. scutisorex
1195. yuumuzik
1196. TyieseMarie
1197. nebace
1198. idealex
1199. bhopsacto
1200. PizzaMolecule
1201. jack9413
1202. itsmassive
1203. kevinjosephjr421
1204. 1mnbvcxz24
1205. silverlightarmada
1206. goldtiger16
1207. s_SpQR
1208. Abhi8192
1209. ricky_af
1210. grekit
1211. weaaman1
1212. Eklasalle
1213. lightraze
1214. jingles
1215. ErnestUlysses
1216. goobersnorf
1217. nextobe
1218. Ubxoxo
1219. AfroSupreme
1220. emBarrosing
1221. WinterFrost
1222. miapow7
1223. jmrevolution
1224. allnitegyme
1225. mcevoyc2014
1226. theflyingbrant
1227. laurenmcg
1228. bahader_shah974
1229. Kiskiyu
1230. slmrma
1231. winkywizard
1232. Graduated2012
1233. hanita304
1234. veggieswillsaveusall
1235. TongueToe
1236. erraticerror
1237. amal.ka
1238. f4string
1239. canady2009
1240. duchessred
1241. kellyl624
1242. yummybuttertoast
1243. sagemini.6
1244. jakethesnake313
1245. ryanburke52
1246. jackw95
1247. dtlawhon
1248. xX_Throne_Xx
1249. NotValkyrie
1250. CautiousNarwhal
1251. pemmylane
1252. nintendogeDS
1253. GiacomoT
1254. shnksahu
1255. thekerrster
1256. RenownedHack
1257. SCyprian
1258. darshika
1259. surfingslashr
1260. wipakensu
1261. michelleusam
1262. luckybuddy
1263. Nachows
1264. garrettp
1265. ateious
1266. ame23
1267. nicole_63
1268. mskelley11
1269. brenthoelzer
1270. EsraDemir
1271. Vaerius
1272. KillDreameater
1273. rachel127
1274. AccelTurn
1275. abigailsmith.love3
1276. eken
1277. s0fist
1278. tives
1279. axletrees
1280. georgialharper
1281. Joemama1816
1282. fightingthefatman
1283. Acetylcholine
1284. meleanor
1285. kreigos
1286. saifu21
1287. GoldenPineapple
1288. totoron
1289. Nuttellarocks
1290. mohd12
1291. meek-seek
1292. painusbrainus
1293. shenteefit
1294. joemagel
1295. l8Dm8mzwHWyM
1296. CDizzle
1297. PropertyOfMatter
1298. asitbehera93
1299. desirage
1300. Shushi
1301. PolymathMark
1302. spurklefloof
1303. shamarw.
1304. Pawf
1305. Ayaake
1306. joaqizzle
1307. AlaaMalik
1308. amingley2
1309. MetaOne
1310. asian_eleph_ent
1311. chuuke
1312. titmang
1313. Cute_red_head
1314. Psychoborg
1315. Psychoborg
1316. msamdgirl01
1317. Ohr
1318. tdanskin
1319. doof2000
1320. phoenix_cielo
1321. potatosalad420
1322. unicornonacid5
1323. beccasfitblr
1324. joehunt1991
1325. zeynepgokturk
1326. Alexandria.Doney
1327. ac07
1328. alfrecruz
1329. beccabeast
1330. goldmine_velvet
1331. Marissrar
1332. vijaypradhan
1333. Joy.Zaia7
1334. Jsmarcelin
1335. aiman4894
1336. obi_oma87
1337. laurasanchez14
1338. fueler_die
1339. -garebear-
1340. kmmadan7
1341. HuzaifahQ
1342. megandavis6
1343. najrit
1344. ElephantMemories
1345. regina.r.cecil
1346. Chelsey016
1347. camden11
1348. charlotteingham01
1349. Brandosees
1350. 0x7270-3001
1351. Kerniza01
1352. aimerloo246
1353. townsleyr
1354. xirrin
1355. gomarinko
1356. nwg416
1357. ibenedetti
1358. Ignus
1359. akhan
1360. crispy
1361. Shaneo5
1362. mich3ll31221
1363. Maddiezeller
1364. hstanley03653
1365. Veritas177
1366. brittneyturnbull
1367. kayleyjasmine
1368. psicocat
1369. Aldios
1370. fatimapharma
1371. ksimp126
1372. kcoyle37
1373. Ira595
1374. rebeccalleee
1375. Ianthe
1376. srestrepor
1377. neostache
1378. amiranda86
1379. Swaggertrains
1380. ariellynn4
1381. kristinhackett
1382. addictGK
1383. aliya12
1384. MANENA2005
1385. hunter.chelsea
1386. foreverthewanderer
1387. Cupcake_batter_is_bae
1388. thedlap
1389. ninanelly
1390. malone_kiera
1391. cdubbs
1392. aspt
1393. tmwalker
1394. euphorialive
1395. marcussandou
1396. Esongbirdie
1397. sabrinaureddit
1398. eladieu
1399. Krazikrissy
1400. perfectionist714
1401. braedenwaddell
1402. Kat_Lee
1403. fatima1898
1404. griffinagatha
1405. adriennevalhalla
1406. haleyk1001
1407. mcroes
1408. poiu6386
1409. Yklym
1410. whittaker123
1411. Brent1044
1412. yadav1998ayushi
1413. tcheifner
1414. alush
1415. mckennaslone
1416. cp142311
1417. indecisivemess
1418. Oneironautilus
1419. regan_elizabeth22
1420. 14trava
1421. annasoto
1422. sally.albright
1423. CobaltSthenia
1424. gracia
1425. Lacrymosa
1426. 16auracloud
1427. e-lectra-heart
1428. DDS2312
1429. Goldtiger18
1430. Oliver_Steven_Assheuer
1431. Hutsonm2
1432. Jw1290
1433. Abbszieske
1434. karalynnesk
1435. Patricia2812
1436. gareth
1437. duchesslia
1438. Hbshaka
1439. Ynattirb.85
1440. user000965
1441. Vedika
1442. noelle
1443. iamalurker
1444. magik
1445. Jennifer8134
1446. Wol525532
1447. TalieFane
1448. Farahzeineddin
1449. Ragzingro
1450. Bshakey1
1451. eulb42
1452. spookyfoster
1453. sophiedbizzle
1454. rastamouse
1455. jennifuretc
1456. Peeweeluver
1457. Louxzs72
1458. Eheitman
1459. taylorwilson
1460. Shehra
1461. potatogenuis
1462. Slade12
1463. hammam
1464. eliment
1465. blackiszero
1466. StudentPC
1467. ssampson95
1468. Ink_my_umbrella
1469. maxlucine
1470. shilezi
1471. THCourtney
1472. devv
1473. i_love_bearss
1474. kentrish
1475. Aquaman
1476. Pixtiny
1477. sazzyb
1478. mrroc
1479. nayann
1480. Katedouglas116
1481. littlekidsyeah
1482. Minerva
1483. honeybee97
1484. C_Starr1
1485. AdelaideDoyle
1486. evankuma2
1487. itisurdestiny
1488. aimeeecourtt
1489. probablynotbrian
1490. mohammedddd
1491. cause
1492. Hasita12345.
1493. geenahml
1494. egb12b
1495. olivia.raples
1496. Zulubulldog
1497. BerryHearts
1498. SirMoustache
1499. Mindover
1500. shrillviolin
1501. h.jehou
1502. amberrroni
1503. Maznate
1504. videshpa
1505. Geggintifoo
1506. harami
1507. reneenz
1508. TBLIXXXY
1509. Gracied091
1510. cas1515
1511. gallelog
1512. Brewjnr
1513. Amebegoya
1514. saraesmaili
1515. karmakay_
1516. Mjt.ibiza
1517. Emrah1980