-1+11570 
Basic Biochemistry

Humans adapt to technology very easily. We can drive cars without knowing what’s under the hood. We can use computers and smartphones much the same way. Among all the different pieces of technology used by us, an obvious but often overlooked example is that of our own body. Not many of us think about the Biochemistry that is always taking place in our body.

This course will link everyday experiences with topics that lie at the core of Biochemistry.

By studying how our body transforms sugars, fats, and the proteins, we will follow the transformations of the food stuffs in our breakfasts, lunches and dinners. We will read lectures from Nobel Laureates, we will peer into the active sites of enzymes, and we see how modern medicine deals with things going wrong.

COURSE FLYER

Lectures
Prerequisites

Some organic chemistry.

Syllabus

This course will taught in an essay-type format on Reddit.

SYLLABUS

At its core Biochemistry really deals with two direct yet deceptively simple questions. These are: (1) where did it come from, and (2) where does it go?

Lecture 1 -- The hemoglobin-oxygen complex: We will use the two core biochemical questions to interrogate the hemoglobin-oxygen complex. We will touch upon heme biosynthesis and breakdown, oxygen transport to the cells, and the expression and degradation of proteins.

Lecture 2 -- The Electron Transport Chain and Oxidative Phosphorylation: We will trace the source of electrons that are added to oxygen to generate water. We will also learn how a gradient of protons is converted into ATP.

Lecture 3 – Structures: We will focus on the structures of FADH2 and NADH. We will also play close attention to the structures of folate, guanine, adenine, uracil, thymine, cytosine, thiamine and pyridoxine. We will bank on the knowledge of these structures for the familiarity we need as we journey deeper into Biochemistry.

Lecture 4 – The high-carb meal: We will eat a high carbohydrate meal, (in our imaginations) and then we will herd the carbons of glucose down the glycolysis pathway, and around the TCA cycle. Then, we will travel with these electrons up the Electron Transport Chain, all the way to oxygen, to make water.

Lecture 5 -- Glycogen and Fatty Acids: We will store some carbohydrates as glycogen, and we will funnel some of the carbon from carbohydrates into fatty acids. We will also study glycogen breakdown and fatty acid breakdown.

Lecture 6 – The high-fat, high-cholesterol meal: We will eat a 4-egg cheese omelet (again in our imaginations) and learn how lipids are digested, how they are packaged and shipped into the blood stream. We will also travel on a few different lipid cargo-ships in our blood stream.

Lecture 7 – The all-meat meal. We will study protein digestion, and the urea cycle. By now, all of us should be experts at herding carbons into the TCA cycle.

Lecture 8 – Purines and Pyrimidines: We will ask the two core biochemical question to the molecules that make up our DNA. Understandably, in cancerous tissues these biosynthetic pathways work overtime, and we will see how some anticancer treatments are based on chemically inhibiting these pathways.

Additional information

GENERAL DISCLAIMER: This aim of this course is to provide an overview of Biochemistry, and to convey its importance to a general audience. Selected topics from Biochemistry are presented to the best of my own ability and current understanding. However, it is possible that some of my presentations may not fit with what is commonly accepted. In those cases, the student is to give less importance to my presentations, and to give more importance to the concepts that fit with what is commonly accepted. This is an evolving course, and I appreciate feedback.

Teacher qualifications

PhD, Medicinal Chemistry.

Latest Update
Lecture 8 is now online (2013-07-02 19:59:56)

"The FINAL lecture on PYRIMIDINES AND PURINES is now online.

I hope you all enjoyed this course.

If you haven't already, please evaluate the course by clicking on this Survey Link

Thanks. "

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909. babusona422
910. AlexMotorcycles
911. salthoff
912. cheesecakeandtea
913. Samson
914. 101124
915. synthetichug
916. minor6th
917. purpleskyy
918. alys_smile
919. teddy16426
920. deboadesida
921. Machtuebernahme
922. Richo1337
923. kkitburi
924. Mystery
925. OnlineLearner
926. rutushe
927. anya5
928. ThisisNOTbono2
929. Ena
930. gpereira
931. vaidatje
932. seidskald
933. cmajor13
934. HappyPanther
935. kataleesi
936. smilesrevolution
937. Dalmaciasikang1
938. SaraJamous
939. captpunkrogers
940. njflyguy
941. Verbery
942. cschwarz3
943. noztre
944. benyadigg
945. burubaxair
946. kunena08
947. Buck_Cletus_the_third
948. nuraaqillah
949. Vdaae
950. EvilEgg
951. KaminskL
952. xhyperamp
953. Ayama
954. TKDPlatypus
955. noahproductions
956. Lamatam
957. nasbelyakova
958. Tallkobben
959. nelsonng
960. romodinho
961. divagat3
962. Bibi12
963. nuni_maimuni
964. expansion
965. RBM
966. espada18
967. ChickenSammich
968. seanknight
969. sumwun21
970. IamGideon
971. lkfjlkrnfrr
972. takamahu
973. yukikat19
974. dahimes
975. sangsami
976. cfergani8
977. zackman558
978. ElizabethStanley
979. dumiaz
980. tylerspears6
981. Ssiyanwal
982. starskip
983. evdoyle
984. arianasvm
985. Jasminesky
986. gargambagel
987. mojojo
988. serenataco
989. sobh
990. bwhauf
991. jusdreinjusdaun
992. lorrainemarden
993. __hsams__
994. cioly
995. Durumu
996. cmiles
997. 07_
998. lilithsposse
999. zellekley
1000. SchizoPsychoMan
1001. treversotiropoulos
1002. PanPIp
1003. the_intoxicologist
1004. conquestinvividcolor
1005. evagavgiotaki
1006. caiotemon
1007. krampulus
1008. Reubanman
1009. christhepolakk
1010. kaltien
1011. bigcockatiels
1012. rsiva98
1013. JemmaD0508
1014. gravynsfw
1015. irawkz
1016. topkek
1017. bar_rachman
1018. DuesExMachina96
1019. purpletomato
1020. Markovic
1021. nofapemergency
1022. blindarrow02
1023. Mete0r1t3
1024. shaynee
1025. sevenstarsofstef
1026. aalowell
1027. ToneF
1028. bobbiburrows2
1029. raremagikarp
1030. silanderhatche
1031. scott.li
1032. Lilt_Bridge
1033. denitsa.harizanova
1034. sabinasosman
1035. Thorhey
1036. Flazze
1037. almusbahi23
1038. antnh1
1039. illusivedude
1040. LEVLEARN
1041. samybouisri
1042. osbornhodges2000
1043. Lanaaa
1044. dowserjr
1045. mmmori
1046. sakura_fantasix
1047. bomfilho
1048. cnading
1049. nishai
1050. AlbertFlasher
1051. cranbronkey
1052. sarah.muschiol
1053. kayeels
1054. mariluzgarcia
1055. lkira
1056. spinsurgeon
1057. jayneeee
1058. morganaha
1059. KobaYounes
1060. Veelayouth
1061. inhume
1062. eallin
1063. Monica101
1064. ChairDeBurlap
1065. mikepacas
1066. captaingreek
1067. Brenda3012
1068. AsianWuChink
1069. personiamsomeone
1070. theEMPTYlife
1071. gabbystolton
1072. mtmeador
1073. euclidlyptus
1074. Prototyperip
1075. victoriaferrete
1076. Voldemort
1077. DreDre
1078. fadwa
1079. Hebert002
1080. imStuuuuuck
1081. gracicles13
1082. Macmic21
1083. Clathrin
1084. ElectricSeahorse
1085. konanced
1086. vijayr98
1087. AlphaSapien
1088. esophagor
1089. kd73
1090. naeu
1091. RajatTyagi
1092. schmiter
1093. stickfigure_1715
1094. Phantom1412
1095. dffnflre
1096. nobbs
1097. ayoleah
1098. caliooppub
1099. beshlik
1100. taartun
1101. nlpkid
1102. improvementhiiip
1103. VaultGirl
1104. JaiEzikeil
1105. MooseRuse
1106. cmdrcaboose2
1107. Fullscreen_Math
1108. MTatro
1109. myMasqueradee
1110. Smp
1111. jtazzk
1112. Jayven_Roman
1113. Doominated
1114. abe-solotely-intel
1115. packback1
1116. sud-rhein
1117. youniqesparklez
1118. ejemelihenry
1119. planetarium
1120. ChemLover
1121. Afmoret
1122. spark34
1123. masterboki
1124. Greateggplant
1125. entfish
1126. hashanthisuraweera
1127. d0naLd
1128. Alicia
1129. annastillman
1130. zssmith1994
1131. Paradigmshift68
1132. dinara
1133. desaishrey
1134. RobRod
1135. selits
1136. kijawa
1137. ritatheexplorer
1138. hyperlux
1139. jacobab43
1140. Russont
1141. tha.jokr
1142. msmaddox25
1143. sasuke1992
1144. Syeeric
1145. madhatrabbit
1146. the_oneand_only89
1147. sienaplacino
1148. ArturoMazon
1149. nabill
1150. CehdHab
1151. salman
1152. SeoulBlossom
1153. reedyboy2012
1154. cinemacookie
1155. kantijaya
1156. moodette
1157. ktso
1158. Riana90
1159. rjycnfynby
1160. Gundas3073
1161. 1_crappuccino_pls
1162. Geekadelphia1
1163. greenredidunno
1164. alekseilyushkin
1165. notacurlyfry
1166. jerryedvds
1167. gutubu
1168. jediejr
1169. brichess
1170. budsofmay
1171. naterific
1172. Slas
1173. BioHazard9
1174. Wolf_meets_Raven
1175. lifesfare
1176. balto
1177. Whereabouts-Unknown
1178. InfiniDL
1179. marcusv1
1180. bleepblobbloop
1181. DeccyBrus
1182. ViIVi
1183. nukeduke
1184. SeanBoult
1185. 042smartkid
1186. thecosmicbean
1187. sboco
1188. 100prcntDar
1189. crisbalas
1190. rifraq
1191. Diego1995
1192. scutisorex
1193. yuumuzik
1194. TyieseMarie
1195. nebace
1196. idealex
1197. bhopsacto
1198. PizzaMolecule
1199. jack9413
1200. itsmassive
1201. kevinjosephjr421
1202. 1mnbvcxz24
1203. silverlightarmada
1204. goldtiger16
1205. s_SpQR
1206. Abhi8192
1207. ricky_af
1208. grekit
1209. weaaman1
1210. Eklasalle
1211. lightraze
1212. jingles
1213. ErnestUlysses
1214. goobersnorf
1215. nextobe
1216. Ubxoxo
1217. AfroSupreme
1218. emBarrosing
1219. WinterFrost
1220. miapow7
1221. jmrevolution
1222. allnitegyme
1223. mcevoyc2014
1224. theflyingbrant
1225. laurenmcg
1226. bahader_shah974
1227. Kiskiyu
1228. slmrma
1229. winkywizard
1230. Graduated2012
1231. hanita304
1232. veggieswillsaveusall
1233. TongueToe
1234. erraticerror
1235. amal.ka
1236. f4string
1237. canady2009
1238. duchessred
1239. kellyl624
1240. yummybuttertoast
1241. sagemini.6
1242. jakethesnake313
1243. ryanburke52
1244. jackw95
1245. dtlawhon
1246. xX_Throne_Xx
1247. NotValkyrie
1248. CautiousNarwhal
1249. pemmylane
1250. nintendogeDS
1251. GiacomoT
1252. shnksahu
1253. thekerrster
1254. RenownedHack
1255. SCyprian
1256. darshika
1257. surfingslashr
1258. wipakensu
1259. michelleusam
1260. luckybuddy
1261. Nachows
1262. garrettp
1263. ateious
1264. ame23
1265. nicole_63
1266. mskelley11
1267. brenthoelzer
1268. EsraDemir
1269. Vaerius
1270. KillDreameater
1271. rachel127
1272. AccelTurn
1273. abigailsmith.love3
1274. eken
1275. s0fist
1276. tives
1277. axletrees
1278. georgialharper
1279. Joemama1816
1280. fightingthefatman
1281. Acetylcholine
1282. meleanor
1283. kreigos
1284. saifu21
1285. GoldenPineapple
1286. totoron
1287. Nuttellarocks
1288. mohd12
1289. meek-seek
1290. painusbrainus
1291. shenteefit
1292. joemagel
1293. l8Dm8mzwHWyM
1294. CDizzle
1295. PropertyOfMatter
1296. asitbehera93
1297. desirage
1298. Shushi
1299. PolymathMark
1300. spurklefloof
1301. shamarw.
1302. Pawf
1303. Ayaake
1304. joaqizzle
1305. AlaaMalik
1306. amingley2
1307. MetaOne
1308. asian_eleph_ent
1309. chuuke
1310. titmang
1311. Cute_red_head
1312. Psychoborg
1313. Psychoborg
1314. msamdgirl01
1315. Ohr
1316. tdanskin
1317. doof2000
1318. phoenix_cielo
1319. potatosalad420
1320. unicornonacid5
1321. beccasfitblr
1322. joehunt1991
1323. zeynepgokturk
1324. Alexandria.Doney
1325. ac07
1326. alfrecruz
1327. beccabeast
1328. goldmine_velvet
1329. Marissrar
1330. vijaypradhan
1331. Joy.Zaia7
1332. Jsmarcelin
1333. aiman4894
1334. obi_oma87
1335. laurasanchez14
1336. fueler_die
1337. -garebear-
1338. kmmadan7
1339. HuzaifahQ
1340. megandavis6
1341. najrit
1342. ElephantMemories
1343. regina.r.cecil
1344. Chelsey016
1345. camden11
1346. charlotteingham01
1347. Brandosees
1348. 0x7270-3001
1349. Kerniza01
1350. aimerloo246
1351. townsleyr
1352. xirrin
1353. gomarinko
1354. nwg416
1355. ibenedetti
1356. Ignus
1357. akhan
1358. crispy
1359. Shaneo5
1360. mich3ll31221
1361. Maddiezeller
1362. hstanley03653
1363. Veritas177
1364. brittneyturnbull
1365. kayleyjasmine
1366. psicocat
1367. Aldios
1368. fatimapharma
1369. ksimp126
1370. kcoyle37
1371. Ira595
1372. rebeccalleee
1373. Ianthe
1374. srestrepor
1375. neostache
1376. amiranda86
1377. Swaggertrains
1378. ariellynn4
1379. kristinhackett
1380. addictGK
1381. aliya12
1382. MANENA2005
1383. hunter.chelsea
1384. foreverthewanderer
1385. Cupcake_batter_is_bae
1386. thedlap
1387. ninanelly
1388. malone_kiera
1389. cdubbs
1390. aspt
1391. tmwalker
1392. euphorialive
1393. marcussandou
1394. Esongbirdie
1395. sabrinaureddit
1396. eladieu
1397. Krazikrissy
1398. perfectionist714
1399. braedenwaddell
1400. Kat_Lee
1401. fatima1898
1402. griffinagatha
1403. adriennevalhalla
1404. haleyk1001
1405. mcroes
1406. poiu6386
1407. Yklym
1408. whittaker123
1409. Brent1044
1410. yadav1998ayushi
1411. tcheifner
1412. alush
1413. mckennaslone
1414. cp142311
1415. indecisivemess
1416. Oneironautilus
1417. regan_elizabeth22
1418. 14trava
1419. annasoto
1420. sally.albright
1421. CobaltSthenia
1422. gracia
1423. Lacrymosa
1424. 16auracloud
1425. e-lectra-heart
1426. DDS2312
1427. Goldtiger18
1428. Oliver_Steven_Assheuer
1429. Hutsonm2
1430. Jw1290
1431. Abbszieske
1432. karalynnesk
1433. Patricia2812
1434. gareth
1435. duchesslia
1436. Hbshaka
1437. Ynattirb.85
1438. user000965
1439. Vedika
1440. noelle
1441. iamalurker
1442. magik
1443. Jennifer8134
1444. Wol525532
1445. TalieFane
1446. Farahzeineddin
1447. Ragzingro
1448. Bshakey1
1449. eulb42
1450. spookyfoster
1451. sophiedbizzle
1452. rastamouse
1453. jennifuretc
1454. Peeweeluver
1455. Louxzs72
1456. Eheitman
1457. taylorwilson
1458. Shehra
1459. potatogenuis
1460. Slade12
1461. hammam
1462. eliment
1463. blackiszero
1464. StudentPC
1465. ssampson95
1466. Ink_my_umbrella
1467. maxlucine
1468. shilezi
1469. THCourtney
1470. devv
1471. i_love_bearss
1472. kentrish
1473. Aquaman
1474. Pixtiny
1475. sazzyb
1476. mrroc
1477. nayann
1478. Katedouglas116
1479. littlekidsyeah
1480. Minerva
1481. honeybee97
1482. C_Starr1
1483. AdelaideDoyle
1484. evankuma2
1485. itisurdestiny
1486. aimeeecourtt
1487. probablynotbrian
1488. mohammedddd
1489. cause
1490. Hasita12345.
1491. geenahml
1492. egb12b
1493. olivia.raples
1494. Zulubulldog
1495. BerryHearts
1496. SirMoustache
1497. Mindover
1498. shrillviolin
1499. h.jehou
1500. amberrroni
1501. Maznate
1502. videshpa
1503. Geggintifoo
1504. harami
1505. reneenz
1506. TBLIXXXY
1507. Gracied091
1508. cas1515
1509. gallelog
1510. Brewjnr
1511. Amebegoya
1512. saraesmaili
1513. karmakay_
1514. Mjt.ibiza
1515. Emrah1980
1516. son1609
1517. mancusok
1518. Success20
1519. angelhair116
1520. shivanibp
1521. DarthVader1649
1522. skframe
1523. Dbb1wm
1524. Cranberriesandpecans
1525. deepspacesp3nce
1526. Savy
1527. Mkeita23
1528. Aisha
1529. cswearingen
1530. hezjs
1531. AnkeVDS
1532. i_apoorvaaa
1533. ejreese
1534. nancee_evelyn
1535. kreambeats
1536. jamarsing
1537. jays.maa
1538. CNicholas87
1539. shrance84
1540. teepse
1541. leflyi
1542. ahristotle
1543. Rohith
1544. wanastacio
1545. millardbri
1546. anotherelf
1547. resullivan13
1548. EricaLaganiere
1549. aesalonvii
1550. jaidgossamer
1551. carternicola
1552. Raihan_13
1553. mblackw9
1554. macyaustinn
1555. lydwak
1556. laurengraeff
1557. sebgenvid4213
1558. toiler
1559. Adona
1560. kingzorrah
1561. ashleynwebb99
1562. mandalneha15
1563. yellowhawk1101
1564. mollina2012
1565. babybestbelieve
1566. allyjtoday
1567. staciescousin
1568. Pikabluee
1569. lovely-bones
1570. BrandyDwyer
1571. Julyanne
1572. idgirl2470
1573. manena
1574. deanners
1575. Tmason47
1576. Anj2017
1577. sharmav996
1578. blynn1219
1579. jordanrolsma
1580. somuch_awkward
1581. malina2002
1582. tillytilda
1583. emikomiller
1584. Kmolina
1585. annabellepeters
1586. mm3113
1587. Joyantika
1588. SheryarM
1589. Sammistuart
1590. zflknr
1591. Heinr01
1592. pu77
1593. HeartOfTheDragon
1594. Tooba154
1595. Roma_2002
1596. Monte_Cristo
1597. sdkbeagley
1598. camileunrein
1599. maddieshienn12
1600. Neogalactic54
1601. Eddybigs
1602. Numuruzero
1603. Jay90
1604. bealexandrea
1605. educatedgypsy
1606. TeddyScott
1607. bluebabyboo
1608. issa26
1609. kmariej3
1610. MAHIPAL_KULADIYA
1611. chemarked
1612. Ani.Tau
1613. fsev
1614. Delphinos
1615. miakgro
1616. NothingtoSee
1617. ECmith
1618. dorfalan
1619. Jacofett760
1620. vanessa-caroline
1621. OlethiaAzalea
1622. dimaisuradze
1623. agonizinglylovely
1624. Jinzy
1625. cecilevsl
1626. StevenSinsmore
1627. monicai
1628. bpatel3237
1629. poopertrooper08
1630. gabsca
1631. katenich95
1632. danimctrani
1633. Suffragettecity
1634. LazyResearcher
1635. mralick
1636. ramneekjawandha
1637. MegumiK
1638. dankmetodeath
1639. kaileys2
1640. txredking90
1641. SAndy19595
1642. Dontsneeze
1643. dysprodiums
1644. arnoldsy10
1645. sakshi91
1646. cassmchurch
1647. supercompleto
1648. GunsoSniper
1649. DisillusionedEnigma
1650. Kspruce
1651. MrChristianL
1652. randominternetdad
1653. Tuhfizz
1654. halaahmed35
1655. lanyahm2018
1656. AkshayRD
1657. jaga94
1658. TheGreatMako123
1659. yellow_salamander
1660. wacey.g
1661. wacey.g
1662. wacey.g
1663. jeanettecharmaine
1664. thunderclapthat
1665. hosbone
1666. Soullessjinjer
1667. d3fact0
1668. OrderOfTheAshes
1669. anlayer
1670. Salmael
1671. MsLoreG
1672. soleham9
1673. FightingDreamers03
1674. harjeet
1675. jalibeanqueen
1676. Primerain17
1677. xlovewriterx
1678. JonelBryant
1679. Master_Dolorosa
1680. lyandle
1681. holuc3001
1682. ohREZ
1683. Louna12
1684. AsmiAbdeslam
1685. broanna