-1+11547 
Basic Biochemistry

Humans adapt to technology very easily. We can drive cars without knowing what’s under the hood. We can use computers and smartphones much the same way. Among all the different pieces of technology used by us, an obvious but often overlooked example is that of our own body. Not many of us think about the Biochemistry that is always taking place in our body.

This course will link everyday experiences with topics that lie at the core of Biochemistry.

By studying how our body transforms sugars, fats, and the proteins, we will follow the transformations of the food stuffs in our breakfasts, lunches and dinners. We will read lectures from Nobel Laureates, we will peer into the active sites of enzymes, and we see how modern medicine deals with things going wrong.

COURSE FLYER

Lectures
Prerequisites

Some organic chemistry.

Syllabus

This course will taught in an essay-type format on Reddit.

SYLLABUS

At its core Biochemistry really deals with two direct yet deceptively simple questions. These are: (1) where did it come from, and (2) where does it go?

Lecture 1 -- The hemoglobin-oxygen complex: We will use the two core biochemical questions to interrogate the hemoglobin-oxygen complex. We will touch upon heme biosynthesis and breakdown, oxygen transport to the cells, and the expression and degradation of proteins.

Lecture 2 -- The Electron Transport Chain and Oxidative Phosphorylation: We will trace the source of electrons that are added to oxygen to generate water. We will also learn how a gradient of protons is converted into ATP.

Lecture 3 – Structures: We will focus on the structures of FADH2 and NADH. We will also play close attention to the structures of folate, guanine, adenine, uracil, thymine, cytosine, thiamine and pyridoxine. We will bank on the knowledge of these structures for the familiarity we need as we journey deeper into Biochemistry.

Lecture 4 – The high-carb meal: We will eat a high carbohydrate meal, (in our imaginations) and then we will herd the carbons of glucose down the glycolysis pathway, and around the TCA cycle. Then, we will travel with these electrons up the Electron Transport Chain, all the way to oxygen, to make water.

Lecture 5 -- Glycogen and Fatty Acids: We will store some carbohydrates as glycogen, and we will funnel some of the carbon from carbohydrates into fatty acids. We will also study glycogen breakdown and fatty acid breakdown.

Lecture 6 – The high-fat, high-cholesterol meal: We will eat a 4-egg cheese omelet (again in our imaginations) and learn how lipids are digested, how they are packaged and shipped into the blood stream. We will also travel on a few different lipid cargo-ships in our blood stream.

Lecture 7 – The all-meat meal. We will study protein digestion, and the urea cycle. By now, all of us should be experts at herding carbons into the TCA cycle.

Lecture 8 – Purines and Pyrimidines: We will ask the two core biochemical question to the molecules that make up our DNA. Understandably, in cancerous tissues these biosynthetic pathways work overtime, and we will see how some anticancer treatments are based on chemically inhibiting these pathways.

Additional information

GENERAL DISCLAIMER: This aim of this course is to provide an overview of Biochemistry, and to convey its importance to a general audience. Selected topics from Biochemistry are presented to the best of my own ability and current understanding. However, it is possible that some of my presentations may not fit with what is commonly accepted. In those cases, the student is to give less importance to my presentations, and to give more importance to the concepts that fit with what is commonly accepted. This is an evolving course, and I appreciate feedback.

Teacher qualifications

PhD, Medicinal Chemistry.

Latest Update
Lecture 8 is now online (2013-07-02 19:59:56)

"The FINAL lecture on PYRIMIDINES AND PURINES is now online.

I hope you all enjoyed this course.

If you haven't already, please evaluate the course by clicking on this Survey Link

Thanks. "

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909. evita77
910. babusona422
911. AlexMotorcycles
912. salthoff
913. cheesecakeandtea
914. Samson
915. 101124
916. synthetichug
917. minor6th
918. purpleskyy
919. alys_smile
920. teddy16426
921. deboadesida
922. Machtuebernahme
923. Richo1337
924. kkitburi
925. Mystery
926. OnlineLearner
927. rutushe
928. anya5
929. ThisisNOTbono2
930. Ena
931. gpereira
932. vaidatje
933. seidskald
934. cmajor13
935. HappyPanther
936. kataleesi
937. smilesrevolution
938. Dalmaciasikang1
939. SaraJamous
940. captpunkrogers
941. njflyguy
942. Verbery
943. cschwarz3
944. noztre
945. benyadigg
946. burubaxair
947. kunena08
948. Buck_Cletus_the_third
949. nuraaqillah
950. Vdaae
951. EvilEgg
952. KaminskL
953. xhyperamp
954. Ayama
955. TKDPlatypus
956. noahproductions
957. Lamatam
958. nasbelyakova
959. Tallkobben
960. nelsonng
961. romodinho
962. divagat3
963. Bibi12
964. nuni_maimuni
965. expansion
966. RBM
967. espada18
968. ChickenSammich
969. seanknight
970. sumwun21
971. IamGideon
972. lkfjlkrnfrr
973. takamahu
974. yukikat19
975. dahimes
976. sangsami
977. cfergani8
978. zackman558
979. ElizabethStanley
980. dumiaz
981. tylerspears6
982. Ssiyanwal
983. starskip
984. evdoyle
985. arianasvm
986. Jasminesky
987. gargambagel
988. mojojo
989. serenataco
990. sobh
991. bwhauf
992. jusdreinjusdaun
993. lorrainemarden
994. __hsams__
995. cioly
996. Durumu
997. cmiles
998. 07_
999. lilithsposse
1000. zellekley
1001. SchizoPsychoMan
1002. treversotiropoulos
1003. PanPIp
1004. the_intoxicologist
1005. conquestinvividcolor
1006. evagavgiotaki
1007. caiotemon
1008. krampulus
1009. Reubanman
1010. christhepolakk
1011. kaltien
1012. bigcockatiels
1013. rsiva98
1014. JemmaD0508
1015. gravynsfw
1016. irawkz
1017. topkek
1018. bar_rachman
1019. DuesExMachina96
1020. purpletomato
1021. Markovic
1022. nofapemergency
1023. blindarrow02
1024. Mete0r1t3
1025. shaynee
1026. sevenstarsofstef
1027. aalowell
1028. ToneF
1029. bobbiburrows2
1030. raremagikarp
1031. silanderhatche
1032. scott.li
1033. Lilt_Bridge
1034. denitsa.harizanova
1035. sabinasosman
1036. Thorhey
1037. Flazze
1038. almusbahi23
1039. antnh1
1040. illusivedude
1041. LEVLEARN
1042. samybouisri
1043. osbornhodges2000
1044. Lanaaa
1045. dowserjr
1046. mmmori
1047. sakura_fantasix
1048. bomfilho
1049. cnading
1050. nishai
1051. AlbertFlasher
1052. cranbronkey
1053. sarah.muschiol
1054. kayeels
1055. mariluzgarcia
1056. lkira
1057. spinsurgeon
1058. jayneeee
1059. morganaha
1060. KobaYounes
1061. Veelayouth
1062. inhume
1063. eallin
1064. Monica101
1065. ChairDeBurlap
1066. mikepacas
1067. captaingreek
1068. Brenda3012
1069. AsianWuChink
1070. personiamsomeone
1071. theEMPTYlife
1072. gabbystolton
1073. mtmeador
1074. euclidlyptus
1075. Prototyperip
1076. victoriaferrete
1077. Voldemort
1078. DreDre
1079. fadwa
1080. Hebert002
1081. imStuuuuuck
1082. gracicles13
1083. Macmic21
1084. Clathrin
1085. ElectricSeahorse
1086. konanced
1087. vijayr98
1088. AlphaSapien
1089. esophagor
1090. kd73
1091. naeu
1092. RajatTyagi
1093. schmiter
1094. stickfigure_1715
1095. Phantom1412
1096. dffnflre
1097. nobbs
1098. ayoleah
1099. caliooppub
1100. beshlik
1101. taartun
1102. nlpkid
1103. improvementhiiip
1104. VaultGirl
1105. JaiEzikeil
1106. MooseRuse
1107. cmdrcaboose2
1108. Fullscreen_Math
1109. MTatro
1110. myMasqueradee
1111. Smp
1112. jtazzk
1113. Jayven_Roman
1114. Doominated
1115. abe-solotely-intel
1116. packback1
1117. sud-rhein
1118. youniqesparklez
1119. ejemelihenry
1120. planetarium
1121. ChemLover
1122. Afmoret
1123. spark34
1124. masterboki
1125. Greateggplant
1126. entfish
1127. hashanthisuraweera
1128. d0naLd
1129. Alicia
1130. annastillman
1131. zssmith1994
1132. Paradigmshift68
1133. dinara
1134. desaishrey
1135. RobRod
1136. selits
1137. kijawa
1138. ritatheexplorer
1139. hyperlux
1140. jacobab43
1141. Russont
1142. tha.jokr
1143. msmaddox25
1144. sasuke1992
1145. Syeeric
1146. madhatrabbit
1147. the_oneand_only89
1148. sienaplacino
1149. ArturoMazon
1150. nabill
1151. CehdHab
1152. salman
1153. SeoulBlossom
1154. reedyboy2012
1155. cinemacookie
1156. kantijaya
1157. moodette
1158. ktso
1159. Riana90
1160. rjycnfynby
1161. Gundas3073
1162. 1_crappuccino_pls
1163. Geekadelphia1
1164. greenredidunno
1165. alekseilyushkin
1166. notacurlyfry
1167. jerryedvds
1168. gutubu
1169. jediejr
1170. brichess
1171. budsofmay
1172. naterific
1173. Slas
1174. BioHazard9
1175. Wolf_meets_Raven
1176. lifesfare
1177. balto
1178. Whereabouts-Unknown
1179. InfiniDL
1180. marcusv1
1181. bleepblobbloop
1182. DeccyBrus
1183. ViIVi
1184. nukeduke
1185. SeanBoult
1186. 042smartkid
1187. thecosmicbean
1188. sboco
1189. 100prcntDar
1190. crisbalas
1191. rifraq
1192. Diego1995
1193. scutisorex
1194. yuumuzik
1195. TyieseMarie
1196. nebace
1197. idealex
1198. bhopsacto
1199. PizzaMolecule
1200. jack9413
1201. itsmassive
1202. kevinjosephjr421
1203. 1mnbvcxz24
1204. silverlightarmada
1205. goldtiger16
1206. s_SpQR
1207. Abhi8192
1208. ricky_af
1209. grekit
1210. weaaman1
1211. Eklasalle
1212. lightraze
1213. jingles
1214. ErnestUlysses
1215. goobersnorf
1216. nextobe
1217. Ubxoxo
1218. AfroSupreme
1219. emBarrosing
1220. WinterFrost
1221. miapow7
1222. jmrevolution
1223. allnitegyme
1224. mcevoyc2014
1225. theflyingbrant
1226. laurenmcg
1227. bahader_shah974
1228. Kiskiyu
1229. slmrma
1230. winkywizard
1231. Graduated2012
1232. hanita304
1233. veggieswillsaveusall
1234. TongueToe
1235. erraticerror
1236. amal.ka
1237. f4string
1238. canady2009
1239. duchessred
1240. kellyl624
1241. yummybuttertoast
1242. sagemini.6
1243. jakethesnake313
1244. ryanburke52
1245. jackw95
1246. dtlawhon
1247. xX_Throne_Xx
1248. NotValkyrie
1249. CautiousNarwhal
1250. pemmylane
1251. nintendogeDS
1252. GiacomoT
1253. shnksahu
1254. thekerrster
1255. RenownedHack
1256. SCyprian
1257. darshika
1258. surfingslashr
1259. wipakensu
1260. michelleusam
1261. luckybuddy
1262. Nachows
1263. garrettp
1264. ateious
1265. ame23
1266. nicole_63
1267. mskelley11
1268. brenthoelzer
1269. EsraDemir
1270. Vaerius
1271. KillDreameater
1272. rachel127
1273. AccelTurn
1274. abigailsmith.love3
1275. eken
1276. s0fist
1277. tives
1278. axletrees
1279. georgialharper
1280. Joemama1816
1281. fightingthefatman
1282. Acetylcholine
1283. meleanor
1284. kreigos
1285. saifu21
1286. GoldenPineapple
1287. totoron
1288. Nuttellarocks
1289. mohd12
1290. meek-seek
1291. painusbrainus
1292. shenteefit
1293. joemagel
1294. l8Dm8mzwHWyM
1295. CDizzle
1296. PropertyOfMatter
1297. asitbehera93
1298. desirage
1299. Shushi
1300. PolymathMark
1301. spurklefloof
1302. shamarw.
1303. Pawf
1304. Ayaake
1305. joaqizzle
1306. AlaaMalik
1307. amingley2
1308. MetaOne
1309. asian_eleph_ent
1310. chuuke
1311. titmang
1312. Cute_red_head
1313. Psychoborg
1314. Psychoborg
1315. msamdgirl01
1316. Ohr
1317. tdanskin
1318. doof2000
1319. phoenix_cielo
1320. potatosalad420
1321. unicornonacid5
1322. beccasfitblr
1323. joehunt1991
1324. zeynepgokturk
1325. Alexandria.Doney
1326. ac07
1327. alfrecruz
1328. beccabeast
1329. goldmine_velvet
1330. Marissrar
1331. vijaypradhan
1332. Joy.Zaia7
1333. Jsmarcelin
1334. aiman4894
1335. obi_oma87
1336. laurasanchez14
1337. fueler_die
1338. -garebear-
1339. kmmadan7
1340. HuzaifahQ
1341. megandavis6
1342. najrit
1343. ElephantMemories
1344. regina.r.cecil
1345. Chelsey016
1346. camden11
1347. charlotteingham01
1348. Brandosees
1349. 0x7270-3001
1350. Kerniza01
1351. aimerloo246
1352. townsleyr
1353. xirrin
1354. gomarinko
1355. nwg416
1356. ibenedetti
1357. Ignus
1358. akhan
1359. crispy
1360. Shaneo5
1361. mich3ll31221
1362. Maddiezeller
1363. hstanley03653
1364. Veritas177
1365. brittneyturnbull
1366. kayleyjasmine
1367. psicocat
1368. Aldios
1369. fatimapharma
1370. ksimp126
1371. kcoyle37
1372. Ira595
1373. rebeccalleee
1374. Ianthe
1375. srestrepor
1376. neostache
1377. amiranda86
1378. Swaggertrains
1379. ariellynn4
1380. kristinhackett
1381. addictGK
1382. aliya12
1383. MANENA2005
1384. hunter.chelsea
1385. foreverthewanderer
1386. Cupcake_batter_is_bae
1387. thedlap
1388. ninanelly
1389. malone_kiera
1390. cdubbs
1391. aspt
1392. tmwalker
1393. euphorialive
1394. marcussandou
1395. Esongbirdie
1396. sabrinaureddit
1397. eladieu
1398. Krazikrissy
1399. perfectionist714
1400. braedenwaddell
1401. Kat_Lee
1402. fatima1898
1403. griffinagatha
1404. adriennevalhalla
1405. haleyk1001
1406. mcroes
1407. poiu6386
1408. Yklym
1409. whittaker123
1410. Brent1044
1411. yadav1998ayushi
1412. tcheifner
1413. alush
1414. mckennaslone
1415. cp142311
1416. indecisivemess
1417. Oneironautilus
1418. regan_elizabeth22
1419. 14trava
1420. annasoto
1421. sally.albright
1422. CobaltSthenia
1423. gracia
1424. Lacrymosa
1425. 16auracloud
1426. e-lectra-heart
1427. DDS2312
1428. Goldtiger18
1429. Oliver_Steven_Assheuer
1430. Hutsonm2
1431. Jw1290
1432. Abbszieske
1433. karalynnesk
1434. Patricia2812
1435. gareth
1436. duchesslia
1437. Hbshaka
1438. Ynattirb.85
1439. user000965
1440. Vedika
1441. noelle
1442. iamalurker
1443. magik
1444. Jennifer8134
1445. Wol525532
1446. TalieFane
1447. Farahzeineddin
1448. Ragzingro
1449. Bshakey1
1450. eulb42
1451. spookyfoster
1452. sophiedbizzle
1453. rastamouse
1454. jennifuretc
1455. Peeweeluver
1456. Louxzs72
1457. Eheitman
1458. taylorwilson
1459. Shehra
1460. potatogenuis
1461. Slade12
1462. hammam
1463. eliment
1464. blackiszero
1465. StudentPC
1466. ssampson95
1467. Ink_my_umbrella
1468. maxlucine
1469. shilezi
1470. THCourtney
1471. devv
1472. i_love_bearss
1473. kentrish
1474. Aquaman
1475. Pixtiny
1476. sazzyb
1477. mrroc
1478. nayann
1479. Katedouglas116
1480. littlekidsyeah
1481. Minerva
1482. honeybee97
1483. C_Starr1
1484. AdelaideDoyle
1485. evankuma2
1486. itisurdestiny
1487. aimeeecourtt
1488. probablynotbrian
1489. mohammedddd
1490. cause
1491. Hasita12345.
1492. geenahml
1493. egb12b
1494. olivia.raples
1495. Zulubulldog
1496. BerryHearts
1497. SirMoustache
1498. Mindover
1499. shrillviolin
1500. h.jehou
1501. amberrroni
1502. Maznate
1503. videshpa
1504. Geggintifoo
1505. harami
1506. reneenz
1507. TBLIXXXY
1508. Gracied091
1509. cas1515
1510. gallelog
1511. Brewjnr
1512. Amebegoya
1513. saraesmaili
1514. karmakay_
1515. Mjt.ibiza
1516. Emrah1980
1517. son1609
1518. mancusok
1519. Success20
1520. angelhair116
1521. shivanibp
1522. DarthVader1649
1523. skframe
1524. Cwt6199
1525. Dbb1wm
1526. Cranberriesandpecans
1527. deepspacesp3nce
1528. Savy
1529. Mkeita23
1530. Aisha
1531. cswearingen
1532. hezjs
1533. AnkeVDS
1534. i_apoorvaaa
1535. ejreese
1536. nancee_evelyn
1537. kreambeats
1538. jamarsing
1539. jays.maa
1540. CNicholas87
1541. shrance84
1542. teepse
1543. leflyi
1544. ahristotle
1545. Rohith
1546. wanastacio
1547. millardbri
1548. anotherelf
1549. resullivan13
1550. EricaLaganiere
1551. aesalonvii
1552. jaidgossamer
1553. carternicola
1554. Raihan_13
1555. mblackw9
1556. macyaustinn
1557. lydwak
1558. laurengraeff
1559. sebgenvid4213
1560. toiler
1561. Adona
1562. kingzorrah
1563. ashleynwebb99
1564. mandalneha15
1565. yellowhawk1101
1566. mollina2012
1567. babybestbelieve
1568. allyjtoday
1569. staciescousin
1570. Pikabluee
1571. lovely-bones
1572. BrandyDwyer
1573. Julyanne
1574. idgirl2470
1575. manena
1576. deanners
1577. Tmason47
1578. Anj2017
1579. sharmav996
1580. blynn1219
1581. jordanrolsma
1582. somuch_awkward
1583. malina2002
1584. tillytilda
1585. emikomiller
1586. Kmolina
1587. annabellepeters
1588. mm3113
1589. Joyantika
1590. SheryarM
1591. Sammistuart
1592. zflknr
1593. Heinr01
1594. pu77
1595. HeartOfTheDragon
1596. Tooba154
1597. Roma_2002
1598. Monte_Cristo
1599. sdkbeagley
1600. camileunrein
1601. maddieshienn12
1602. Neogalactic54
1603. Eddybigs
1604. Numuruzero
1605. Jay90
1606. bealexandrea
1607. educatedgypsy
1608. TeddyScott
1609. bluebabyboo
1610. issa26
1611. kmariej3
1612. MAHIPAL_KULADIYA
1613. chemarked
1614. Ani.Tau
1615. fsev
1616. Delphinos
1617. miakgro
1618. NothingtoSee
1619. ECmith
1620. dorfalan
1621. Jacofett760
1622. vanessa-caroline
1623. OlethiaAzalea
1624. dimaisuradze
1625. agonizinglylovely
1626. Jinzy
1627. cecilevsl
1628. StevenSinsmore
1629. monicai
1630. bpatel3237
1631. poopertrooper08
1632. gabsca
1633. katenich95
1634. danimctrani
1635. Suffragettecity
1636. LazyResearcher
1637. mralick
1638. ramneekjawandha
1639. MegumiK
1640. dankmetodeath
1641. kaileys2
1642. txredking90
1643. SAndy19595
1644. Dontsneeze
1645. dysprodiums
1646. arnoldsy10
1647. sakshi91
1648. cassmchurch
1649. supercompleto
1650. GunsoSniper
1651. DisillusionedEnigma
1652. Kspruce
1653. MrChristianL
1654. randominternetdad
1655. Tuhfizz
1656. halaahmed35